Using Regional Real-World Evidence to Shift Clinical Practice Across Asia
Challenge
Despite strong global evidence supporting intensive cholesterol management for secondary cardiovascular prevention, adoption across parts of Asia remained inconsistent.
Clinical hesitancy surrounding long-term use of high-intensity statin therapy persisted due to perceived tolerability and safety concerns in Asian patient populations, contributing to variation in treatment practices and suboptimal risk reduction.
Approach
A multi-country evidence generation and scientific engagement strategy was developed to address regional practice barriers using locally relevant data and expert leadership.
Key initiatives included:
Identifying and aligning leading cardiovascular experts across Asia around a unified evidence-generation strategy focused on regional clinical needs.
Establishing a pragmatic approach to real-world evidence development using large-scale healthcare database resources capable of generating meaningful population-level insights.
Supporting collaborative analysis, publication, and dissemination of regionally relevant outcomes data in partnership with academic investigators.
Enabling expert-led scientific education and peer-to-peer engagement to translate emerging evidence into clinical practice discussions across multiple countries.
Outcome
The initiative contributed to:
Increased regional confidence in evidence-based cholesterol management strategies for secondary cardiovascular prevention.
Broader adoption of intensive lipid-lowering approaches in clinical practice discussions and treatment recommendations.
Strengthened collaboration between academic leaders and healthcare stakeholders across multiple Asian markets.
Greater recognition of the importance of locally generated real-world evidence in informing regional healthcare decisions.
Key Insight
Combining locally relevant evidence generation with coordinated expert engagement can accelerate changes in clinical practice and improve adoption of evidence-based care.